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GLP-1 and GLP-2 Orchestrate intestine integrity, gut microbiota, and immune system crosstalk
doi: 10.1007/s10620-024-08720-2 96 ClarkeLPassamRTFalaheeBJirapinyoPAllegrettiJRKellyCR
Both preclinical and clinical studies have demonstrated that GLP-1s modulate the gut microbiota composition by delaying gastric emptying and altering luminal glucose ( Firmicutes Lachnospiraceae and Clostridiales ), alongside an increase in Proteobacteria (e.g., Burkholderiales bacterium YL45 ) and Akkermansia muciniphila a species largely associated with high-fibre diets and mucosal barrier health (6971)
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